Indoxacarb

CAS Number:173584-44-6 Yes

UNII :52H0D26MWR

UN number:     UN 3077

Chemical formula:C22H17ClF3N3O7

Molar mass:    527.84 g·mol−1

Melting point: 88.1 °C (190.6 °F; 361.2 K) 99% indoxacarb PAI

Indoxacarb is a white powdered solid material formulated as a wettable granule and soluble concentrate. Indoxacarb is considered a suitable, "low-toxicity", synthetic organophosphate replacement. Pest control products containing Indoxacarb as an active ingredient are typically used on a wide range of crops for ants, roaches, and other sucking pests.

Indoxacarb is an oxadiazine pesticide developed by Tuhong that acts against lepidopteran larvae. It is marketed under the names Indoxacarb Technical Insecticide, Steward Insecticide and Avaunt Insecticide. It is also used as the active ingredient in Syngenta line of commercial pesticides: Advion and Arilon.

Indoxacarb begins working when target pests either come into contact with the chemical or ingest treated foliage and fruit. Once absorbed or ingested, Indoxacarb inhibits the flow of sodium ions into nerve cells, resulting in impaired nerve function, inability to feed, paralysis, and eventually death. This process begins immediately but it may take several days for the insect to die.

Its main mode of action is via blocking of nerve sodium channels. It is fairly lipophilic with a Kow of 4.65. This pesticide should be used with caution since some insects such as the oriental tobacco budworm (Helicoverpa assulta) become resistant when exposed.

Household products

Indoxacarb is the active ingredient in a number of household insecticides, including cockroach and ant baits, and can remain active after digestion. Indoxacarb is the active ingredient in the new pet product, Activyl from Merck Animal Health. It is marketed to kill fleas on dogs and cats.

Toxicity to humans

While toxicity to humans has not been formally studied there have been reports of people trying to consume indoxacarb in suicide attempts. Consumption of indoxocarb can cause acute onset of methemoglobinemia.[8] Methemoglobinemia is a condition which ultimately decreases the effectiveness of red blood cells to exchange oxygen with organs. Methemoglobinemia can be fatal if left untreated, but proper treatment of this condition can rapidly begin reversing it.